Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-01-02
2007-01-02
Jiang, Shaojia Anna (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S053000, C514S055000, C536S018700, C536S020000, C536S055200, C536S055300, C536S124000, C252S182270
Reexamination Certificate
active
10688585
ABSTRACT:
Therapeutic 5-aminosalicylic acid derivative compositions having general formula (I), wherein R is a 1-deoxy sugar residue or a poly(ethylene glycol) chain-containing residue, are provided. The compositions enable topical delivery of 5-aminosalicylic acid to the gastrointestinal tract following oral administration in pharmaceutical preparations. According to the invention, the compositions stabilize pharmaceutical compositions containing therapeutic 5-aminosalicylic acid derivatives in a manner that enhances the retention of said compositions in the intestine, decreases the cellular absorption thereof, and decreases the transfer of said compositions or the 5-aminosalicylic acid derived therefrom to the systemic circulation
REFERENCES:
Tjoernelund et al, Journal of Chromatography, “Stability of 5-Aminosalicylic Acid and its Metabolites in Plasma at −° C: Formation of N-β-D-Glucopyranosyl-5-Aminosalicylic Acid”, 1991, vol. 570, No. 1, pp. 224-228.
Tjoernelund et al reference, Xenobiotica, “New Metabolites of the Drug 5-Aminosalicylic Acid I: N-β-D-Glucopyranosyl-5-Aminosalicylic Acid”, 1989, vol. 19, No. 8, pp. 891-899.
Barta Kent
Jiang Shaojia Anna
Nelson Deanna J.
White Everett
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