Aminoquinolones as GSK-3 inhibitors

Details Aminoquinolones as GSK-3 inhibitors Aminoquinolones as GSK-3 inhibitors

2007-03-13

2011-11-22

Royds Draper, Leslie A. (Department: 1614)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S312000, C514S277000, C546S152000

Reexamination Certificate

active

08063221

ABSTRACT:
Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases.

REFERENCES:
patent: 3536809 (1970-10-01), Applezweig
patent: 3598123 (1971-08-01), Zaffaroni et al.
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: 4008719 (1977-02-01), Theeuwes et al.
patent: 4044126 (1977-08-01), Cook et al.
patent: 4364923 (1982-12-01), Cook et al.
patent: 4414209 (1983-11-01), Cook et al.
patent: 4762831 (1988-08-01), Grohe et al.
patent: 4847375 (1989-07-01), Grohe et al.
patent: 4990508 (1991-02-01), Narita et al.
patent: 5033252 (1991-07-01), Carter
patent: 5052558 (1991-10-01), Carter
patent: 5059595 (1991-10-01), Le Grazie
patent: 5073543 (1991-12-01), Marshall et al.
patent: 5120548 (1992-06-01), McClelland et al.
patent: 5153203 (1992-10-01), Yatsunami et al.
patent: 5190923 (1993-03-01), Vincent et al.
patent: 5323907 (1994-06-01), Kalvelage
patent: 5354556 (1994-10-01), Sparks et al.
patent: 5387748 (1995-02-01), Demuth, Jr. et al.
patent: 5430152 (1995-07-01), Saukaitis et al.
patent: 5591767 (1997-01-01), Mohr et al.
patent: 5612059 (1997-03-01), Cardinal et al.
patent: 5639476 (1997-06-01), Oshlack et al.
patent: 5639480 (1997-06-01), Bodmer et al.
patent: 5674533 (1997-10-01), Santus et al.
patent: 5709874 (1998-01-01), Hanson et al.
patent: 5733566 (1998-03-01), Lewis
patent: 5739108 (1998-04-01), Mitchell
patent: 5759542 (1998-06-01), Gurewich
patent: 5798119 (1998-08-01), Herbig et al.
patent: 5840674 (1998-11-01), Yatvin et al.
patent: 5891474 (1999-04-01), Busetti et al.
patent: 5900252 (1999-05-01), Calanchi et al.
patent: 5922356 (1999-07-01), Koseki et al.
patent: 5972366 (1999-10-01), Haynes et al.
patent: 5972891 (1999-10-01), Kamei et al.
patent: 5980945 (1999-11-01), Ruiz
patent: 5985307 (1999-11-01), Hanson et al.
patent: 5993855 (1999-11-01), Yoshimoto et al.
patent: 6004534 (1999-12-01), Langer et al.
patent: 6039975 (2000-03-01), Shah et al.
patent: 6045830 (2000-04-01), Igari et al.
patent: 6048736 (2000-04-01), Kosak
patent: 6060082 (2000-05-01), Chen et al.
patent: 6071495 (2000-06-01), Unger et al.
patent: 6087324 (2000-07-01), Igari et al.
patent: 6113943 (2000-09-01), Okada et al.
patent: 6120751 (2000-09-01), Unger
patent: 6131570 (2000-10-01), Schuster et al.
patent: 6139865 (2000-10-01), Friend et al.
patent: 6197350 (2001-03-01), Yamagata et al.
patent: 6221633 (2001-04-01), Ertl et al.
patent: 6221897 (2001-04-01), Frick et al.
patent: 6245744 (2001-06-01), Frick et al.
patent: 6248363 (2001-06-01), Patel et al.
patent: 6253872 (2001-07-01), Neumann
patent: 6264970 (2001-07-01), Hata et al.
patent: 6267981 (2001-07-01), Okamoto et al.
patent: 6271359 (2001-08-01), Norris et al.
patent: 6274552 (2001-08-01), Tamarkin et al.
patent: 6316652 (2001-11-01), Steliou
patent: 6342512 (2002-01-01), Kirsch et al.
patent: 6350458 (2002-02-01), Modi
patent: 6376461 (2002-04-01), Igari et al.
patent: 6419961 (2002-07-01), Igari et al.
patent: 6589548 (2003-07-01), Oh et al.
patent: 6613358 (2003-09-01), Randolph et al.
patent: 6699500 (2004-03-01), Okada et al.
patent: 6740634 (2004-05-01), Saikawa et al.
patent: 6825353 (2004-11-01), Saito et al.
patent: 6967205 (2005-11-01), Abdul-Rahman
patent: 2004/0132764 (2004-07-01), Locher
patent: 2005/0054663 (2005-03-01), Bennett et al.
patent: 2005/0182085 (2005-08-01), Defossa et al.
patent: 1181381 (1997-11-01), None
patent: 1491944 (2004-04-01), None
patent: 0 265 230 (1988-04-01), None
patent: 0 390 215 (1990-10-01), None
patent: 0 945 435 (1999-09-01), None
patent: 1 486 488 (2004-12-01), None
patent: 1 650 192 (2006-04-01), None
patent: 206819 (1992-05-01), None
patent: S59-1489 (1984-01-01), None
patent: 62198685 (1986-02-01), None
patent: S62-53987 (1986-05-01), None
patent: S62-167769 (1987-01-01), None
patent: S62-252772 (1987-04-01), None
patent: S63-264439 (1988-01-01), None
patent: S63-132891 (1988-06-01), None
patent: 03133983 (1989-10-01), None
patent: H1-268679 (1989-10-01), None
patent: H5-25162 (1993-02-01), None
patent: WO 97/26265 (1997-07-01), None
patent: WO 97/41097 (1997-11-01), None
patent: WO 98/08871 (1998-03-01), None
patent: WO 99/15525 (1999-04-01), None
patent: WO 99/65897 (1999-12-01), None
patent: WO 00/38675 (2000-07-01), None
patent: WO 00/40569 (2000-07-01), None
patent: WO 00/63208 (2000-10-01), None
patent: WO 00/66585 (2000-11-01), None
patent: WO 00/71549 (2000-11-01), None
patent: WO 00/78312 (2000-12-01), None
patent: WO 01/09111 (2001-02-01), None
patent: WO 01/83451 (2001-11-01), None
patent: WO 01/85695 (2001-11-01), None
patent: WO 02/04462 (2002-01-01), None
patent: WO 02/09758 (2002-02-01), None
patent: WO 02/17918 (2002-03-01), None
patent: 02/04462 (2002-06-01), None
patent: WO 02/092571 (2002-11-01), None
patent: 2004/019932 (2003-08-01), None
patent: WO 2004/089930 (2004-10-01), None
patent: WO 2004/096221 (2004-11-01), None
patent: WO 2005/007111 (2005-01-01), None
patent: WO 2009/035634 (2009-03-01), None
patent: WO 2009/035684 (2009-03-01), None
Singh et al., Synthesis and antibacterial activity of 7-hydrazinoquinolones, 1998, Eur. J. Med. Chem., vol. 33, pp. 697-703.
Wentland, et al., Synthesis and Bacterial DNA Gyrase Inhibitory Properties of a Spirocyclopropylquinolone Derivative, J. Med. Chem. 31:1694-1697, 1988.
Kiely, et al., New “Ofloxacin” Type Antibacterial Agents. Incorporation of the Spiro Cyclopropyl Group at N-1. J. Med. Chem. 31:2004-2008, 1988.
Calas, et al., Relation structure-activité dans la série des quinolones, Eur. J. Med. Chem. 26:279-290, 1991.
Wentland, et al, Relationship of Structure of Bridged (2,6-Dimethyl-4-Pyridinyl)-Quinolones to Mammalian Topoisomerase II Inhibition, Bioorg. Med. Chem Lett. 3 (8) 1711-1716, 1993.
Toda, et al., Pyridonecarboxylic Acids as Antibacterial Agents IX1a)Synthesis and Structure—Activity Relationship of 3-Substituted 10-(1-Aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acids and Their 1-Thio and 1-Aza Analogues2), Chem. Pharm. Bull 42 (12) 2569-2574, 1994.
Golub, et al., Evaluation of 3-carbooxy-4(1H)-quinolones as inhibitors of human protein kinase CK2, J. Med. Chem 49: 6443, 2006.
Asakawa, et al., Cocaine-Amphetamine-Regluated Transcript Influences Energy Metabolism, Anxiety and Gastric Emptying in Mice, Horm. Metab.Re. 33(9):554-58, 2001.
Atarashi, et al., Synthesis and Antibacterial Activities of Optically Active Ofloxacin and Its Fluoromethyl Derivative, Chem. Pharm. Bull. 35(5):1896-902, 1987.
Buchwald, et al., Long-Term, Continuous Intravenous Heparin Administration by an Implantable Infusion Pump in Ambulatory Patients with Recurrent Venous Thrombois, Surgery 88(4):507-16, 1980.
Coghlan, et al., Selective Small Molecule Inhibitors of Glycogen Synthase Kinase-3 Modulate Glycogen Metabolism and Gene Transcription, Chemistry & Biology 7(10):793-03, 2000.
Doyle, et al., Alkyl Nitrite-Metal Halide Deamination Reactions. 2. Substitutive Deamination of Arylamines by Alkyl Nitrites and Copper (II) Halides. A Direct and Remarkably Efficient Conversion of Arylamines to Aryl Halides, J. Org. Chem. 42(14): 2426-31, 1977.
Fujita, et al., 5-Alkoxyimidazoquinolones as Potential Antibacterial Agents. Synthesis and Structure—Activity Relationships, Chem. Pharm. Bull. 44(5):987-90, 1996.
Guo, H., et al., 5-amino-S-methoxy Quinolone Carboxylic Acid Derivatives and Its Preparation, Inst. Med. Biol. Tech. Chin, Abstract, 2004.
Haq, et al., Glycogen Synthase Kinase-3β is a Negative Regulator of Cardiomyocyte Hypertrophy, J. Cell. Biol. 151(1):117-29, 2000.
Havlicek, et. al., Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds, J. Med. Chem. 40:408-12, 1997.
Kiely, et al., A General Method for the Preparation of 2-Substituted-4-oxo-3-Quinolinecarboxylic Acids, J. Heterocyclic Chem. 26(6):1675-81, 1989.
Kim, et al., GSK3, a Master Switch

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