Aminoquinoline derivatives, preparation method thereof and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S312000

Reexamination Certificate

active

08049014

ABSTRACT:
Provided are a novel aminoquinoline compound represented by Formula 1 or a pharmaceutically acceptable salt thereof, preparation method thereof, and a pharmaceutical composition for preventing or treating cutaneous cancer, comprising the aminoquinoline compound or pharmaceutically acceptable salt thereof. Since the compound of Formula 1 exhibits excellent anti-proliferative effect on melanoma tumor cells, it is useful for preventing or treating cutaneous cancer.wherein R1, R2, and R3are defined in the specification.

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patent: 6384051 (2002-05-01), Frost et al.
patent: 7425564 (2008-09-01), Fujiwara et al.
patent: WO 96/09294 (1996-03-01), None
patent: WO 2006/108059 (2006-10-01), None
patent: WO 2008/048375 (2008-04-01), None
Office Action issued by the Korean Patent Office on Feb. 1, 2011 in connection with corresponding Korean Patent Application No. 10-2009-00025560.
Scott M. Wilhelm et al., “Bay 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis,” Cancer Research 64, 7099-7109, Oct. 1, 2004.

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