Aminopyrimidine derivatives as antiviral agents for respiratory

Details Aminopyrimidine derivatives as antiviral agents for respiratory Aminopyrimidine derivatives as antiviral agents for respiratory

1993-03-17

1993-10-26

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31505

Patent

active

052566684

ABSTRACT:
Antiviral activity against respiratory syncytial virus has been found in some substituted 6-aminopyrimidines having the formula: ##STR1## wherein R.sup.1 is lower alkyl, preferably methyl or t-butyl, R.sup.2 is halogen or cyano, and R.sup.3 is C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n R.sup.4 where n is 1 or 2 and R.sup.4 is phenyl, phenyl substituted by lower alkoxy, lower alkyleneoxy, bromo, or 3,4-methylenedioxy; 3 or 4-pyridinyl, pyridinyl substituted by cyano or bromo, thienyl, or di-(C.sub.1 -C.sub.6 alkyl)amino.

REFERENCES:
patent: 4505910 (1985-03-01), Bagli
patent: 4617393 (1986-10-01), Bagli et al.
patent: 4980355 (1990-12-01), Zondler et al.
patent: 5002949 (1991-03-01), Peseckis et al.
Belshe and Hay, J. Respiratory Diseases 10:552-561 (1989).
Bagli et al., J. Med. Chem. 31, 814-823 (1988).

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