Aminopyridine derivatives having Aurora A selective...

Details Aminopyridine derivatives having Aurora A selective... Aminopyridine derivatives having Aurora A selective...

2005-10-25

2009-02-17

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S336000

Reexamination Certificate

active

07491720

ABSTRACT:
The present invention relates to a compound represented by the general formula (I):wherein m1and m2are 1, 2, or 3; n1and n2are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Raiand Rai′ is hydrogen atom, etc. and Rbjand Rbj′ is hydrogen atom, etc.; Rc, Rd, and Reare hydrogen atom, etc; X1is CH, CX1a, or N; X2is CH, N, etc.; X3is CH, N, etc.; X4is CH or N; Y1, Y2, and Y3are each independently CH or N; Z1and Z2are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

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