Aminopyridine compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142278, 5142355, 5142358, 5142365, 5142372, 514318, 514326, 514341, 544 60, 544124, 544360, 546193, 546215, 546275, 546276, 546278, 546306, 546307, 546308, A61K 31495, A61K 3154, C07D40100, C07D21156

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active

053710860

ABSTRACT:
An aminopyridine compound represented by the formula: ##STR1## wherein n represents 0 or 1; Z represents .dbd.S, .dbd.NCN or .dbd.CHNO.sub.2 ; R.sub.1 represents --NR.sub.3 R.sub.4, --NHNR.sub.3 R.sub.4, --NHCONHR.sub.3 or --NHSO.sub.2 R.sub.3 ; R.sub.2 represents H, or substituted or unsubstituted alkyl; R.sub.3 and R.sub.4, which may be the same or different, represent H, substituted or unsubstituted alkyl, aryl, substituted or unsubstituted acyl or alkoxycarbonyl group; and R.sub.3 and R.sub.4 may form a heterocyclic ring together with a nitrogen atom to which R.sub.3 and R.sub.4 are bound, through another heteroatom or without it; an optical isomer thereof or art acid salt thereof, which is excellent in pharmacological effect and repressed in side effects as a drug for circulatory diseases.

REFERENCES:
patent: 4057636 (1977-11-01), Peterson
patent: 4436911 (1984-03-01), Studt et al.
patent: 4496573 (1985-01-01), Studt et al.
patent: 4787931 (1988-11-01), Henri, II et al.
patent: 4808722 (1989-02-01), Henrie, II
patent: 4818271 (1989-04-01), Henrie, II
Novikov et al, CA 70-77727v (1967).

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