Aminophenoxyacetic acid derivatives and pharmaceutical...

Details Aminophenoxyacetic acid derivatives and pharmaceutical... Aminophenoxyacetic acid derivatives and pharmaceutical...

2006-02-14

2006-02-14

Tsang, Cecillia J. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S307000, C514S314000, C514S318000, C514S321000, C514S323000, C546S141000, C546S144000, C546S192000, C546S193000, C546S201000

Reexamination Certificate

active

06998401

ABSTRACT:
There is provided an aminophenoxyacetic acid derivative of the following formula (I):wherein, R1, R2, R3and R4are, independent from each other, alkoxy group, alkyl group or aryl group, etc.; E1and E2are oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is pheny group which may be substituted or benzoyl group, etc,or a pharmaceutically acceptable salt thereof.These compounds have neuroprotective effects by inducing calbindin D28Kd, one of Ca2+-binding proteins.

REFERENCES:
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M.P. Mattson et al,Neuron, 6(1):41-51 (1991).
J. Hugon et al,Brain Res., 707(2):288-292 (1996).

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