Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1985-09-18
1987-12-22
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
530330, 530331, 530332, C07K 5506, C07K 5508
Patent
active
047147571
ABSTRACT:
Aminopeptidase inhibitory activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo-substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl or heteroaryl;
REFERENCES:
patent: 4636560 (1987-01-01), Godfrey, Jr. et al.
Allinger et al, "Organic Chemistry", 1971, pp. 494-497, Worth Publishers.
Umezawa et al., J. Antibiotics, vol. 29, pp. 97-99 (1976).
Ocain et al., Ninth American Peptide Symposium, University of Toronto, Toronto, Ontario, Canada, Jun. 23-28, 1985.
Umezawa et al., J. Antibiotics, vol. 29, pp. 100-101 (1976).
Delaney Norma G.
Godfrey Jr. Jollie D.
Gordon Eric M.
Barrack Donald J.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Nutter Nathan M.
Phillips Delbert R.
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