Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-08-08
2006-08-08
Nashed, Nashaat T. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S069100, C435S252330, C435S254210, C435S320100, C536S023200
Reexamination Certificate
active
07087422
ABSTRACT:
The object of the present invention is to provide Koji mold aminopeptidases capable of efficiently hydrolyzing persistent peptides and also genes encoding the aminopeptidases. The present invention providesAspergillus nidulansaminopeptidase and nucleic acid molecules encoding it. In particular, the present invention provides a protein having an amino acid sequence represented by amino acid Nos. 1 to 519 in SEQ ID NO: 2, or a protein containing the substitution, deletion, insertion, addition or inversion of one or more amino acids in said sequence, and which protein has an activity of catalyzing the reaction for releasing an amino acid at an N-terminal of a peptide, and nucleic acid molecules encoding them.
REFERENCES:
patent: 195 26 485 (1997-01-01), None
patent: 0 359 164 (1990-03-01), None
patent: 0 794 253 (1997-09-01), None
patent: 1 036 843 (2000-09-01), None
patent: 9-294583 (1997-11-01), None
patent: 11-346777 (1999-12-01), None
patent: 2000-325090 (2000-11-01), None
patent: 975797 (1982-11-01), None
patent: WO 96/15504 (1996-05-01), None
patent: WO 96/28542 (1996-09-01), None
patent: WO 98/14599 (1998-04-01), None
patent: WO 98/51163 (1998-11-01), None
patent: WO 98/51803 (1998-11-01), None
Seffernick, J. L., et al., 2001, “Melamine deaminase and atrazine chlorohydolase: 98 percent identical but functionally different”, Journal of Bacteriology, vol. 183, No. 8, pp. 2405-2410.
S. Kunihiro, et al., “A Polymerase Chain Reaction-Based Method for Cloning Novel Members of a Gene Family Using a Combination of Degenerate and Inhibitory Primers”, Gene, 289, (2002), pp. 177-184.
R. Cueva, et al., “Yeast Vacuolar Aminopeptidase YSCI Isolation and Regulation of the APE1 (LAP4) Structural Gene”, Published by Elsevier Science Publishers B.V., vol. 259, No. 1, pp. 125-129, Dec. 1989.
Y. Chang, et al., Molecular Cloning and Sequencing of Genomic DNA Encoding Aminopeptidase I fromSaccharomyces cerevisiae, The Journal of Biological Chemistry, vol. 264, No. 12, Apr. 25, 1989, pp. 6979-6983.
R. Trumbly, et al., “Isolation and Characterization of Aminopeptidase Mutants ofSaccharomyces cerevisiae”, Journal of Bacteriology, vol. 156, No. 1, Oct. 1983, pp. 36-48.
T. Nakadai, et al., “Purification and Properties of Leucine Aminopeptidase IV fromAspergillus Oryzae”, Agric. Biol. Chem., 1977, 41(9), pp. 1657-1666.
T. Nakadai, et al., “Purification and Properties of Leucine Aminopeptidase III fromAspergillus Oryzae”, Agr. Biol. Chem., 1973, 37 (4), pp. 775-782.
T. Nakadai, et al., “Purification and Properties of Leucine Aminopeptidase III fromAspergillus Oryzae”, Agr. Biol., Chem. 1973, 37 (4), pp. 767-774.
T. Nakadai, et al., “Purification and Properties of Leucine Aminopeptidase I fromAspergillus Oryzae”, Agr. Biol. Chem., 1973, 37 (4), pp. 757-765.
P. A. Vankuyk, et al., Fungal Genetics and Biology, vol. 29, pp. 201-210, “Analysis of TwoAspergillus NidulansGenes Encoding Extracellular Proteases”, 2000.
A. M. Blinkovsky, et al., Biochimica et Biophysica Acta, vol. 1480, pp. 171-181, “A Non-Specific Aminopeptidase fromAsperillus”, 2000.
G.-D. Lee, et al., Journal of Applied Microbiology, vol. 84, XP-002288598, pp. 561-566, “Purification and Properties of an Extracellular Leucine Aminopeptidase from theBacillus Sp.N2”, Sep., 1998.
Kitamoto Katsuhiko
Koibuchi Kyoko
Kojima Mari
Maruyama Jun-ichi
Ninomiya Daiki
Ajinomoto Co. Inc.
Moore William W.
Nashed Nashaat T.
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