Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-02-11
1994-06-21
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546242, 546246, A61K 31445, C07D21140, C07D21126
Patent
active
053228529
ABSTRACT:
The invention relates to compounds of formula I ##STR1## wherein either R.sub.1 is a radical of formula Ia,
REFERENCES:
patent: 5086051 (1992-02-01), James et al.
patent: 5169867 (1992-12-01), Stanek et al.
Bell et al "Polyamines as intermediates in developmental neurotoxic events" CA 106:45043q (1987).
Bacchi. et al "Effects of the ornithine decarboxylase inhibitors. . . " CA 106:168537m (1987).
Breitenstein et al "EGME inhibits rat embryo ODC activity" CA 106:133263s (1987).
RN 112640-06-9, RN 96740-42-0 structure.
Chemical Abstracts 104:30840g. Khomutov et al. Aminooxy propylamine as an effective inhibitor of ornithine decarboxylase in vitro and in vivo. Bioorg. Khim. (1985).
Chemical Abstracts 108:131324e corresponding to FR 2,593,502. (1986).
Prabhu et al. "Synthesis and Structure-Activity Relationships of Selected Tricyclic Oxime O-Ethers as Potential Anticholinergic Agents". J. Pharm. Sci. 70, 558-562 (1981).
Grishina et al. "First Asymmetric Synthesis of 4-Piperidones. Preparation of Optically Active Diastereomers of 1-.alpha.-Phenylethy1-2-methyl-4-Piperidone". Chem. Het. Comp. 21, pp. 1132-1136 (1985).
Mistryukov. "Effect of Electrostatic Factors on the Stereochemistry of the Hydride Reduction of Ketones of the Piperidine Series". Bull. Acad. Sci. USSR Div. Chim. Sci. (Eng) 965, pp. 1788-1796 (1965).
Hodjat et al. "Aminomercuration X-Synthese D'Heterocycliques Monospiranniques par Aminomercuration Intramoleculaire". J. Heterocycl. Chem. 9, pp. 1081-1086 1972.
Casy et al. "Synthesis and Stereochemistry of Diastereoisomeric 1,3-Dimethylpiperidin-4-ols and Related Compounds". Can. J. Chem, 50, pp. 803-809 (1972).
LeBel et al. "Stereospecific Synthesis of 2,3,6-Trisubstituted Piperidines: An Efficient Total Synthesis of (.noteq.)-Pumiliotoxin C". J. Am. Chem. Soc. 111, pp. 3363-3368 (1989).
Nazarov et al. "Heterocyclic Compounds. Communication XXIX. Stereoisomerism of 2,5-Dimethyl-4-Piperidinol, 1,2,5-trimethyl-4-piperidinol, and their derivatives". Bull. Acad. Sci. USSR, Div. Chim. Sci. (English), 1954, pp. 65-76 (1954).
Chemical Abstracts 57:2183d, corresponding to Chizhov, "ZH. Obshch. Khim." 31, pp 3469-3477 (1961).
Campbell et al. "Studies on .gamma.-Pyrones, II. Synthesis of 4-Piperidinols from Pyrones". J. Org. Chem. 15, pp. 337-342 (1950).
Grochowski et al. "A New Synthesis of O-Alkylhydroxylamines". Synthesis 1976, pp. 682-684 (1976).
Pankanskie et al. "An Improved Synthetic Route to Aminoxypropylamine (APA) and Related Homologs". Synthetic Commun. 19, pp. 339-344 (1989).
Frei Jorg
Stanek Jaroslav
Chang Celia
Ciba-Geigy Corp.
Fishman Irving M.
Ivy C. Warren
Kaiser Karen G.
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