Aminonaphthacene derivatives and their use

Details Aminonaphthacene derivatives and their use Aminonaphthacene derivatives and their use

1982-08-11

1985-09-10

Raymond, Richard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

260365, 514467, 514533, 514534, 514546, 514548, 514550, 514617, 514628, 514630, 514656, 544 89, 549451, 549452, A61K 3113, C07C 9707

Patent

active

045406952

ABSTRACT:
Aminonaphthacene derivatives of the formula: ##STR1## wherein A is either one of the following groups: ##STR2## wherein R.sup.1 is a hydrogen atom or a group of the formula: --COR.sup.7, R.sup.2 and R.sup.3 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group or an oxo group, R.sup.4 and R.sup.5 are both hydrogen atoms or either one of them is a hydrogen atom and the other is a group of the formula: --COR.sup.7, R.sup.6 is a hydrogen atom, a hydroxyl group or a group of the formula: --OCOR.sup.7 and R.sup.7 is a lower alkyl group, a halo(lower)alkyl group, a phenyl group or a halophenyl group, which are useful as anti-microbial and/or anti-tumor agents, or as intermediates in their production.

REFERENCES:
patent: 1922480 (1933-08-01), Koehler
patent: 4104306 (1978-08-01), Bernstein et al.
patent: 4107423 (1978-08-01), Arcamone et al.
patent: 4302398 (1981-11-01), Hassall et al.
Arcamone, "Doxorubicin--Anticancer Antibiotics", (Medicinal Chemistry--a Series of Monographs; published by Academic Press, New York), 1981, (Table of Contents and pp. 163-193 and 259-299).

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