Aminonaphthacene derivatives and their production

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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260365, 260376, 260380, 2603511, 514227, 514280, 514282, 514463, 514325, 514680, 544154, 544380, 544381, 549451, A01N 4384, C07C 5016, C07C 9726, C07C 4968

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046109862

ABSTRACT:
A (7S,9S) isomer or its racemic modification of the aminonaphthacene derivative of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R.sup.2 is a hydrogen atom or a hydroxyl group, R.sup.3 and R.sup.4 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group or an oxo group, A is an ethylene group optionally bearing at least one lower alkyl and Q is a hydroxyl group, a lower alkoxy group or a dimethylamino group, or an acid addition salt thereof, which is useful as an anti-tumor agent.

REFERENCES:
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patent: 4077988 (1978-03-01), Arcamone et al.
patent: 4089872 (1978-05-01), Koert et al.
Acton et al, J. Med. Chem., vol. 22, No. 8, pp. 922-926 (1979).
Gssery et al, J. Med. Chem., vol. 22, No. 11, pp. 1425-1428 (1979).
Inaba et al, Cancer Research, vol. 39, pp. 2200-2203 (Jun. 1979).

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