Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1984-06-29
1986-10-14
Sneed, Helen M. S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
546 2, 549206, C07F 722
Patent
active
046174095
ABSTRACT:
The invention concerns a method of preparation of aminomethyltriorganotin compounds, preferably .alpha.-mono or disubstituted, the new tin compounds obtained thereby and an application of said tin compounds to the synthesis of aminomethylorganometallic compounds and to the regiospecific preparation of .beta.-aminoalcohols. The intermediate tin and metallic compounds are new. The method for preparing the tin compounds comprises reacting an iminium salt with a corresponding stannylanion, preferably a triorganostannylanion. This method provides best yields and provides regiospecific .beta.-aminoalcohols useful by having in most cases a large spectrum of pharmacological activities.
REFERENCES:
patent: 3723089 (1973-03-01), Peterson
patent: 4472429 (1984-09-01), Drabek
patent: 4504488 (1985-03-01), Davis
Abel et al., J. Organometallic Chem. 97, 159-165 (1975).
Lequan et al., J. Organometallic Chem. 113, C13-C16 (1976).
Peterson et al., J. Organometallic Chem. 66, 209-217 (1974).
Peterson, J. Organometallic Chem. 21, p63-p64 (1970).
Peterson et al., JACS 93(16), pp. 4027-4031 (1971).
Elissando Bernard
Pereyre Michel
Quintard Jean-Paul
Centre National de la Recherche Scientifique
Sneed Helen M. S.
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