Aminomethylindans, -benzofurans and -benzothiophenes

Details Aminomethylindans, -benzofurans and -benzothiophenes Aminomethylindans, -benzofurans and -benzothiophenes

1997-10-22

1999-10-26

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514200, 514212, 514320, 514401, 514402, 514408, 514422, 514443, 514456, 514595, 514659, 540596, 540609, 546196, 546202, 546205, 5483164, 548525, 548579, 548950, 548962, 548967, 549 49, 549462, 564 52, 564928, A61K 31445, C07D40512

Patent

active

059729643

ABSTRACT:
Compounds of formula I ##STR1## wherein R1.dbd.(cyclo)alk(en)yl, aralkyl, alkyl(oxy)carbonyl, CONH2, etc.; R2.dbd.H, (cyclo)alk(en)yl, aralkyl, etc.; R3-R5.dbd.H, halo, alkyl, alkoxy, etc.; R6,R7.dbd.H, alkyl; R6R7.dbd.atoms to complete a ring; R8,R9.dbd.groups cited for R2, 2-oxoimidazolidinoalkyl, etc.; NR8R9=heterocyclyl; 1 of X,Y=CH2 and the other.dbd.CH2, O, S were prepd. Thus, 1-indancarboxylic acid was converted in 5 steps to 1-(N,N-dipropylaminomethyl)-6-formylaminoindane oxalate which had ED50 of 0.0055.mu.M/kg s.c. in the 8--OH DPAT cue agonism test in rats.

REFERENCES:
patent: 3980658 (1976-09-01), Possanza et al.
patent: 4500543 (1985-02-01), Debernardis et al.
patent: 4530932 (1985-07-01), Clemence et al.
patent: 4670447 (1987-06-01), Strupczewski
patent: 4847254 (1989-07-01), Boegesoe et al.
patent: 4861789 (1989-08-01), Berge
patent: 4946863 (1990-08-01), Boegesoe et al.
patent: 5130334 (1992-07-01), Arrowsmith
patent: 5196454 (1993-03-01), Grauert
patent: 5225596 (1993-07-01), Carlsson
patent: 5561152 (1996-10-01), Freeman
Ahlennis, Pharm. Tox., 64:3 (1989).
Cerro et al., Eur. J. Pharm., 158:53 (1988).
DeBernardis et al., J. Med. Chem., 28:1398 (1985).
Gillis et al., J. Pharm. Exp. Ther., 248:851 (1989).
Glitz, D. A.. et al., Drugs, 41:11 (1991).
Hicks, Life Science, 47:1609 (1990).
Hyttel et al., J. Neurolchem., 44:1615 (1985).
Lowe et al., J. Med. Chem., 34:1860 (1991).
Martin et al., J. Med. Chem., 32:1052 (1991).
Pedersen et al., Acta Pharmacol. Toxicol., 31:488-96 (1972).
Prehn, Eur. J. Pharm., 203:213 (1991).
Saxena et al., Pharmacology of Antihypertensive Therapeuties, Handb. Exp. Pharm., 93 Springer Verlag, pp. 533-558 (1990).
Saxena et al., Trends Pharm. Sci. II, 95 (1990).
Sanchez, C. et al., Drug Dev. Res., 22:239-50 (1991).
Schipper, Human Psychopharm., 6:S53 (1991).
Tonoue, T. et al., Psychoneuro-endocrinology, 11:177-84 (1986).
Tricklebank, M.D. et al., Euro. J. Pharmacol, 133:47-56 (1987).
Van Hest, Psychopharm, 107:474 (1992).
Wadenberg et al., (1991), J. Neural Transm., 83:43.
DeBernardis et al., J. Med. Chem., 28:1398:1404 (1985).
Perregaard et al., CA 124:232261) (1995).

Affiliated with

Also associated with

Rating

Aminomethylindans, -benzofurans and -benzothiophenes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aminomethylindans, -benzofurans and -benzothiophenes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminomethylindans, -benzofurans and -benzothiophenes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-764981