Aminomethylindans, -benzofuranes and -benzothiophenes

Details Aminomethylindans, -benzofuranes and -benzothiophenes Aminomethylindans, -benzofuranes and -benzothiophenes

1995-06-06

1998-09-15

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514372, 514373, 514379, 514414, 514444, 546196, 546202, 546205, 546269, 546274, 546285, 5483151, 5483154, 5483164, 548525, 548527, 548528, C07D40512, C07D41112, A61K 3134, A61K 3138

Patent

active

058078894

ABSTRACT:
Compounds of formula I ##STR1## wherein R1=(cyclo)alk(en)yl, aralkyl, alkyl(oxy)carbonyl, CONH2, etc.; R2=H, (cyclo)alk(en)yl, aralkyl, etc.; R3-R5=H, halo, alkyl, alkoxy, etc.; R6,R7=H, alkyl; R6R7=atoms to complete a ring; R8,R9=groups cited for R2, 2-oxoimidazolidinoalkyl, etc.; NR8R9=heterocyclyl; 1 of X,Y=CH2 and the other=CH2, O, S were prepd. Thus, 1-indancarboxylic acid was converted in 5 steps to 1-(N,N-dipropylaminomethyl)-6-formylaminoindane oxalate which had ED50 of 0.0055.mu.M/kg s.c. in the 8-OH DPAT cue agonism test in rats.

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