Aminomethylene-peptides as immunosuppressants

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514315, 514423, 546225, 546227, 546245, 548530, 548531, 548532, A61K 31445, C07D21132, C07D20710

Patent

active

053859189

ABSTRACT:
Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, n, X.sup.1 and Z are defined in the specification.

REFERENCES:
Dutta et al "Prolin Derivatives", CA 102: 135502f (1985).
Rubini et al "Synthesis and Isosteric Methylene-oxy Pseudodipeptide Analogues as Novel Amide Bond Surrogate Units" Tetrahedron 42 (25) 6039-6045 (1986).

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