Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1996-03-22
2000-05-23
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
549412, 549408, 549410, C07D41304, C07D31158
Patent
active
060667311
ABSTRACT:
A process for the production of a Mannich reagent comprises reacting formaldehyde, especially paraformaldehyde, with a secondary amine in the complete or almost complete absence of a solvent. An alternative comprises reacting a diaminomethane produced from a secondary amine, formaldehyde, especially paraformaldehyde, as well as water with one another in about equimolar amounts. The invention is also concerned with a process for the aminomethylation of .delta.-tocopherol or of tocopherol mixtures containing this and comprises using a Mannich reagent which has been produced in the above manner. After completion of this aminomethylation process excess Mannich reagent can be separated by distillation and can be reacted with water and formaldehyde, especially paraformaldehyde, in order to regenerate further Mannich reagent suitable for use in the aminomethylation, this regeneration representing a further aspect of the invention. Finally, the invention includes certain novel bis(aminomethyl)-.gamma.-tocopherols.
REFERENCES:
patent: 2486539 (1949-11-01), Weisler
patent: 2519863 (1950-08-01), Weisler
patent: 4977282 (1990-12-01), Baldwin et al.
patent: 5229521 (1993-07-01), Luisoli et al.
Nakamura, et al., Studies on Tocopherol Derivatives. I. Conversion of .beta.-,.gamma.-, and .delta.Tocopherol to .alpha.-Tocopherol, Chem. Pharm. Bull. vol. 19 (11) pgs 2318-2324, 1971.
Abstract of EP 319 834, (1989) (WPAT).
Muller Robert Karl
Schneider Heinz
Cave LLP Bryan
Haracz Stephen M.
Keating Dominic
Richter Johann
Roche Vitamins Inc.
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