Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-31
2007-07-31
Shameem, Golam (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S151000, C548S302100
Reexamination Certificate
active
10508329
ABSTRACT:
This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof.The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament.(In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6and R7: the same or different from one another and each represents H or the like.Provided that R3does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4represents a group other than Me when m is 1, R1is OH or OMe and Alk1is a C1-3alkylene, and further 1) when X is a bond, n is 1 and R3is H, or 2) when X is a bond, n is 0 and R3is cyclohexane.)
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Fujiyasu Jiro
Hayashibe Satoshi
Itahana Hirotsune
Okada Masamichi
Toya Takashi
Astellas Pharma Inc.
Cheng Karen
Shameem Golam
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