Aminomethyl-substituted 2,3-dihydropyrano[2,3-b]pyridines and th

Details Aminomethyl-substituted 2,3-dihydropyrano[2,3-b]pyridines and th Aminomethyl-substituted 2,3-dihydropyrano[2,3-b]pyridines and th

1992-06-11

1993-10-05

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142245, 544 33, 546115, 546116, C07D491052, A61K 31435

Patent

active

052505405

ABSTRACT:
Aminomethyl-substituted 2,3-dihydropyrano[2,3-b]pyridines can be prepared by alkylation of corresponding amines. The novel aminomethyl-substituted dihydropyrano[2,3-b]pyridines can be used as active ingredients in medicaments, in particular for the treatment of disorders of the central nervous system.

REFERENCES:
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Chemical Abstracts, vol. 96, No. 25, Jun. 21, 1982, p. 740, paragraph No. 217799j, Columbus, Ohio, US: Dr. Pratap et al.: "Phenoxyalkylamines in semirigid conformation: synthesis and pharmacological activity of N1-(4'-chromanyl)-N4-arylpiperazines and N1-(2'-chromanylmethyl)-N4-arylpiperazines" & Indian J. Chem., Sect. B 1981, vol. 20 B, No. 12, pp. 1063-1067, Example III.
G. Burrell et al, "Variation in the Aromatic Ring of Cromakalim: . . . ", J. Med. Chem. 33 (11) pp. 3023-3027 (1990.
R. Sarges et al, "Spiro Hydantoin Aldose Reductase Inhibitors . . . ", J. Med. Chem. 33 (7), pp. 1859-1865 (1990).
Beilstein 2, p. 197, 201, 250, 278; (1920).
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