Aminomethyl derivatives of biologically active substances, and e

Details Aminomethyl derivatives of biologically active substances, and e Aminomethyl derivatives of biologically active substances, and e

1986-09-12

1989-07-04

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514258, 514261, 514266, 514274, 514947, 544 82, 544256, 544277, 544313, 544317, A61K 31495, C07D23910, C07D47328

Patent

active

048450812

ABSTRACT:
N-methylamino derivatives of biologically active substances which have enhanced delivery across topical membranes and pharmaceutical compositions adapted for topical administration containing same.

REFERENCES:
Bundgaard and Johansen, "Prodrugs as Drug Delivery Systems IV . . . " Journal of Pharmaceutical Sciences, vol. 69, No. 1, Jan. 1980, pp. 44-46.
Chem. Abstracts 97 (1982), Abst. No. 182353a, Kundu, "N-Alkylated Derivatives of 5-Fluorouracil".
Bundgaard and Johansen, "Pro-Drugs as Drug Delivery Systems XV . . . " Int. Journal of Pharmaceutics 7 (1980), pp. 129-136.
Johansen and Bundgaard, "Pro-Drugs as Drug Delivery Systems XXIV . . . " Arch. Pharm. Chemi., Sci. Ed. 1982 10, pp. 111-121.
Pitman, "Pro-Drugs of Amides, Imides, and Amines", Medical Research Reviews vol. 1, No. 2, (1981), pp. 189-214.

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