Aminomethanobenzazocine process

Details Aminomethanobenzazocine process Aminomethanobenzazocine process

1976-09-20

1978-11-28

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D22126

Patent

active

041275772

ABSTRACT:
N-Alkylated-8-aminated-2,6-methano-3-benzazocines, useful as strong analgesics, are prepared by one route comprising reduction of 8-nitro intermediates or by another route comprising Birch type reduction of 8-methoxy intermediates followed by dehydration-rearrangement of the oximes of the resulting 8-oxo intermediates.

REFERENCES:
patent: 3632591 (1972-01-01), Albertson et al.
patent: 3764606 (1973-10-01), Akkerman et al.
patent: 3833595 (1974-09-01), Atsumi et al.
patent: 3876644 (1975-04-01), Henecka et al.
patent: 4009171 (1977-02-01), Albertson
March, J., Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, McGraw Hill, New York, 1968, pp. 776-777, 821-822.
De Stevens, G., Editor, Analgetics, Academic Press, New York, 1965, pp. 11 and 118.
Jacobson, A. E. et al., J. Med. Chem., 8, 563 (1965).

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