Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-12-22
1995-06-13
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514365, 514376, 514438, 514471, 546336, 546337, 548204, 548232, 549 77, 564192, A61K 3134, A61K 31425, C07D21330, C07D21332
Patent
active
054243254
ABSTRACT:
Aminoketone derivatives according to the present invention strongly inhibit thiol protease such as calpain, papain, cathepsin B, cathepsin H, cathepsin L or the like and have excellent properties concerning absorbance on oral administration, tissue distribution and cell membrane permeability. The aminoketone derivatives cart thus be used as therapeutic agents for treating muscular dystrophy, cataract, cardiac infarction, stroke, Alzheimer's disease, amyotrophy, osteoporosis and hypercalcemia and so on. It may also be used as therapeutic agents for preventing metastasis of cancer. In addition, the present derivatives are also applicable as intermediates for the preparation of ketone derivatives, which have inhibitory activity against thiol protease.
Ando Naoko
Ando Ryoichi
Masuda Hirokazu
Morinaka Yasuhiro
Sasaki Toshiro
Cebulak Mary C.
Mitsubishi Kasei Corporation
Raymond Richard L.
LandOfFree
Aminoketone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aminoketone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoketone derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1309569