Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-02-03
1976-11-09
Rizzo, Nicholas S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260283SY, 260288CE, 424258, C09D21722
Patent
active
039910636
ABSTRACT:
New amino-isoquinoline derivatives of the general formula: ##SPC1##
Wherein R.sub.1 and R.sub.4 are the same or different and each represents a hydrogen or halogen atom or an alkyl group, R.sub.2 and R.sub.3 are the same or different and each represents a hydrogen or halogen atom or an alkyl or alkoxy group or R.sub.2 and R.sub.3 together represent a methylenedioxy radical, R.sub.5 represents a hydrogen atom or an alkyl or aryl group and R.sub.6 represents a di (lower alkyl) amino group or a nitrogen containing 5- or 6-membered heterocyclic radical linked to the isoquinoline nucleus either through a carbon atom or through the nitrogen atom such as 2-, 3- or 4-pyridyl, or 1-pyrrolidinyl are described. The aforesaid alkyl and alkoxy groups are preferably lower alkyl and lower alkoxy groups respectively. By the terms "lower alkyl" and "lower alkoxy" as used in this specification are meant straight or branched chain alkyl and alkoxy groups respectively having at most 6 carbon atoms. The preferred aryl group, which may be represented by R.sub.5, is phenyl. The compounds appear effective in respiratory or oxidative processes in living organisms. When R.sub. 6 contains certain nitrogen moieties such as dialkylamino, and certain nitrogen heterocycles are effective economic poisons i.e. rodenticides, bacteriocides and fungicides. In less than toxic doses, the compounds are useful in combatting Chronic Respiratory Disease in poultry and in combatting barbiturate-induced respiratory failure.
REFERENCES:
patent: 3277085 (1966-10-01), Aebi et al.
patent: 3702849 (1972-11-01), Cronin et al.
patent: 3758480 (1973-09-01), Reimlinger et al.
patent: 3775417 (1973-11-01), de Ruiter et al.
Adams Bruce L.
Burns Robert E.
Jaughn Mary C.
Lobato Emmanuel J.
Rizzo Nicholas S.
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