Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-11-21
1999-04-06
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514262, 514383, 514398, 514405, 514407, 544277, 544332, 5482638, 5483301, 5483621, 5483725, A61K 352, C07D47318, C07D47326, C07D23902, C07D24908, C07D23328
Patent
active
058918817
ABSTRACT:
Aminoheterocycle-substituted glycerols of Formula I are disclosed: ##STR1## wherein one of A, B or C is --X--R, wherein X is --O-- or --S--, and R is a substituted or unsubstituted C.sub.12-24 alkyl or alkenyl, the substituent being one or more of halo, C.sub.1-3 alkoxy or cyano, provided that a double bond of the alkenyl does not originate at the carbon atom bound to X; and another of A, B or C is an aminoheterocycle ring substituent --Het--NH.sub.2, wherein Het is a 5 to 11-membered monocyclic, bicyclic or bicyclic fused heterocyclic ring moiety with at least 1 to 4 nitrogens atoms contained within the hetero cyclic moiety, one of which nitrogen atoms is bonded to the glycero carbon; and the remaining A, B, or C substituent is --OH. The compounds of Formula I, isomers, salts, pharmaceutical compositions and appliances incorporating the same, and methods of use thereof are also disclosed.
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Nair Haridasan K.
Peterson Andrew C.
Clarion Pharmaceuticals Inc.
Conte, Esq. Salvatore R.
Higel Floyd D.
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