Aminoheteroaryl compounds as protein kinase inhibitors

Details Aminoheteroaryl compounds as protein kinase inhibitors Aminoheteroaryl compounds as protein kinase inhibitors

2007-06-12

2007-06-12

Tucker, Zachary C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C544S124000, C544S215000, C544S238000, C544S333000, C544S360000, C544S405000, C546S194000, C546S297000

Reexamination Certificate

active

10786610

ABSTRACT:
Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET

REFERENCES:
patent: 6313137 (2001-11-01), Amin et al.
patent: 2006/0046991 (2006-03-01), Cui et al.
patent: 2006/0128724 (2006-06-01), Cui et al.
patent: 0 204 285 (1992-01-01), None
patent: 1 044 967 (2004-08-01), None
patent: 07-109260 (1995-04-01), None
patent: WO 93/15055 (1993-08-01), None
patent: WO 98/37080 (1998-08-01), None
patent: WO 99/55706 (1999-11-01), None
patent: WO 01/00213 (2001-01-01), None
patent: WO 01/60806 (2001-08-01), None
patent: WO 02/056882 (2002-07-01), None
patent: WO 03/000666 (2003-01-01), None
patent: WO 03/045924 (2003-06-01), None
Vippagunta et al, “Crystalline Solids” Advanced Drug Delivery Reviews, vol. 48, pp. 3-26 (2001).
Gavezzotti, “Are Crystal Structures Predictable?” Accounts of Chemical Research, vol. 27, pp. 309-314 (1994).
Hawley's Condensed Chemical Dictionary, 12th ed., Richard J. Lewis, Sr. , © 1993 by Van Nostrand Reinhold, p. 594.
Concise Encyclopedia Chemistry, edited by Drs. Hans-Dieter Jakubke and Hans Jeschkeit, © 1993 by Walter de Gruyter & Co., p. 490.
McGraw-Hill Dictionary of Chemical Terms, 3rd ed. edited by Sybil P. Parker, © 1984 McGraw-Hill, Inc., p. 200.
Bradbury et al., “New Non-peptide Endothelin-A Receptor Antagonists: Synthesis, Biological Properties, and Structure—Activity Relationships of 5-(Dimethylamino)-N-pyridyl-, -N-pyrimidinyl-, -N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides,”J. Med. Chem., 1997, pp. 996-1004, vol. 40, No. 6.
Bristol et al., “An Improved Synthesis of 2-Amino-3-alkyloxypyridines by a Phase-Transfer Catalyzed Ether Synthesis,”Synthesis, Dec. 1981, pp. 971-973, vol. 12.
Dennin, et al., “Synthesis of Derivatives of Pyrazino[1,2-a]pyrimindin-4-ones,”Journal of Heterocyclic Chemistry, Sep.-Oct. 1990, pp. 1639-1643, vol. 27.
Foks et al., “Studies on Pyrazine Derivatives. XXX. Sythesis of Pyrazinylamino-1,3-Diazacycloalkanes of Potential Circulatory Activity,”Acta Poloniae Pharmaceutica, Jan./Feb. 1997, pp. 55-62, vol. 54, No. 1.
Kaminski et al., “Antiulcer Agents. 2. Gastric Antisecretory, Cytoprotective, and Metabolic Properties of Substituted Imidazo[1,2-a]pyridines and Analogues,”J. Med. Chem., 1987, pp. 2031-2046, vol. 30.
Shimomura et al., “Semi-synthetic aequorins with improved sensitivity to Ca2+ions,”Biochem. J., 1989, pp. 913-920, vol. 261.
Sollogoub et al., “First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine,”Tetrahedron Letters, 2001, pp. 3121-3123, vol. 43.
Wisterowicz et al.,Acta Poloniae Pharmaceutica, 1997, pp. 55-62, vol. 54, No. 1.

Affiliated with

Also associated with

Rating

Aminoheteroaryl compounds as protein kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aminoheteroaryl compounds as protein kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoheteroaryl compounds as protein kinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3854852