Aminoguanidine assay and applications thereof

Details Aminoguanidine assay and applications thereof Aminoguanidine assay and applications thereof

1990-02-20

1992-04-28

Warden, Robert J.

Chemistry: analytical and immunological testing

Nitrogen containing

Amine and quaternary ammonium

436808, 436 63, 436161, 422 61, 422 70, 435810, G01N 3300

Patent

active

051089300

ABSTRACT:
A method and associated materials including test kits for detecting and measuring the presence and amount of aminoguanidine and its analogs in biological samples is disclosed. Biological samples may include plasma, urine or tissue, and the present method may be used to determine the activity and effect of aminoguanidine and its analogs, particularly to the extent that such materials are useful as agents to prevent advanced glycosylation of proteins. The present invention extends to a new drug assay, suitable test kits, and to the assessment of kidney function and the potential to aid in the diagnosis of underlying pathologies where kidney dysfunction is a symptom.

REFERENCES:
patent: 4758583 (1988-07-01), Cerami et al.
Beaven et al. "A Specific And Sensitive Assay For Aminoguanidine: Its's Application To A Study Of The Disposition Of Aminoguanidine In Animal Tissue", J. Pharmacol. Exp. Ther., vol. 165, No. 1, 1969, pp. 14-22.

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