Aminoglycoside steroids, a process for their preparation, their

Details Aminoglycoside steroids, a process for their preparation, their Aminoglycoside steroids, a process for their preparation, their

1987-10-29

1989-11-21

Sneed, H. M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514172, 536 5, 536 6, 536 61, 540 90, A61K 3158

Patent

active

048823155

ABSTRACT:
##STR1## Compounds I (either R.sub.1 =OH, C.sub.1 -C.sub.4 alkoxy and R.sub.2 =H, C.sub.1 -C.sub.4 alkyl, or R.sub.1 +R.sub.2 =a chemical bond; R.sub.3 =an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being .alpha. or .beta.) and their pharmaceutically acceptable salts are useful as antihypertensive agents. Their preparation and use as well as pharmaceutical compositions containing them are also described.

REFERENCES:
"Side Reactions During Saponification of Acyl Cardenolides with NH.sub.3 ", Makarevich et al., (1984), Chem. Ass. 102: 185349.
"Zur Stereochemie der Epoxycardanolide (Isogenine)", Krass et al., Helvetica. Chem. Acta. 55(5), 1352-1371.
"Synthesis of Isobufalin Methyl Ester", J.C.S.(CC), 1967, 644-646, Kasturi et al., (1967).
"Inhibition of Potentiation of Ovabain Inotropism by Modified Cardenolides", Davisson et al., (1972), Chem. Asst. 78: 119146.

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