Aminoglycoside composition having substantially reduced nephroto

Details Aminoglycoside composition having substantially reduced nephroto Aminoglycoside composition having substantially reduced nephroto

1990-10-30

1991-08-13

Friedman, Stanley J.

Abrasive tool making process, material, or composition

514 39, A61V 3170

Patent

active

050396668

ABSTRACT:
This invention relates to an aminoglycoside composition having reduced nephrotoxicity induced by the aminoglycoside which comprises a selected aminoglycoside and a compound present in an effective amount selected from the group consisting of (a) at least one 7-(oxoalkyl)1,3-dialkyl xanthine of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are independently selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, straight-chain or branched chain alkoxyalkyl and hydroxyalkyl radicals; and A is a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group; (b) a compound of the formula ##STR2## wherein at least one of R.sub.3 and R.sub.4 is a branched hydroxyalkyl group of the formula ##STR3## with a tertiary alcohol function, which R.sub.6 stands for an alkyl group with 1 to 3 carbon atoms and n stands for a whole number from 2 to 5, the other R.sub.3 or R.sub.4 group that may optionally be present stands for a hydrogen atom or an aliphatic hydrocarbon group R.sub.7 with up to 6 carbon atoms, whose carbon chain may be interrupted by up to 2 oxygen atoms or may be substituted with an oxo group or up to two hydroxyl groups R.sub.5 is an alkyl group having 1 to 4 carbon atoms; and (c) a suitable mixture of the foregoing.

REFERENCES:
patent: 4002742 (1977-01-01), Wright et al.
patent: 4029882 (1977-06-01), Wright
patent: 4235892 (1980-11-01), Nagabhushan

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