Aminoglycoside antibiotics and intermediates therefor

Details Aminoglycoside antibiotics and intermediates therefor Aminoglycoside antibiotics and intermediates therefor

1974-06-04

1977-05-17

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 4, 536 12, 536 17, C07H 1522

Patent

active

040243320

ABSTRACT:
Certain novel derivatives of naturally-occurring aminoglycoside antibiotics such as neamine, kanamycins A and B, 3',4'-dideoxykanamycin B, 3',4'-dideoxy-4,5-dehydrokanamycin B, tobramycin and the gentamicins C.sub.2 and C.sub.1a. The novel derivatives possess an optionally-substituted homo-or heteroarylmethyl group on the nitrogen atom of the aminomethyl moiety at the C-6' position of the natural aminoglycoside and are useful as antibacterial agents.

REFERENCES:
patent: 3282783 (1966-11-01), Vanderhaeghe
Kobayashi et al., The Syns of Kanamycin-6"-Uronic Acid, ect., J. of Antibiotics, vol. 23, 1970, pp. 225-230.
Omoto et al., Separation of Amino Gly. Antibiotics by Gas-Liquid Chrom., J. of Antibiotics, vol. 24, 1971, pp. 430-434.

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