Aminoglycoside antibiotics

Details Aminoglycoside antibiotics Aminoglycoside antibiotics

1974-10-18

1977-02-01

Gotts, Lewis

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07G 1100

Patent

active

040061337

ABSTRACT:
New derivatives of the antibiotic butirosin A having the formula: ##STR1## in which R is a radical of formula (II): ##STR2## and pharmaceutically acceptable acid addition salts thereof. The butirosin A derivatives of formula (I) can be prepared by reduction of a 5"-azido compound having the formula (III): ##STR3## in which R' is the same groups R or a group which, on reduction, gives a group of formula (II).
The butirosin A derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof are active against a broad spectrum of Gram-positive and Gram-negative bacteria, including some butirosin-resistant strains.

REFERENCES:
patent: 3784541 (1974-01-01), Culbertson et al.
patent: 3826802 (1974-07-01), Kawaguchi et al.
Culbertson, T. P. "5"-Amino-deoxybutirosin-", J. of Antibiotics, vol. 26, No. 26, 1973, pp. 790-792.

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