Aminoglycoside antibiotic compounds

Details Aminoglycoside antibiotic compounds Aminoglycoside antibiotic compounds

1978-05-18

1980-10-28

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 17R, C07H 1522

Patent

active

042308470

ABSTRACT:
Selective blocking of some amino groups in a polyamino organic compound having at least one pair of available neighboring hydroxyl and amino groups is effected by first preparing in situ transition metal salt complexes of available neighboring amino and hydroxyl group pairs in said polyamino organic compound, followed by introduction of blocking groups on the non-complexed amino groups and, finally, removing the transition metal cations from the selectively N-blocked polyamino organic compound complex to obtain a polyamino organic compound having selectively blocked amino groups.
This process is particularly valuable when carrying out aminocyclitol-aminoglycoside transformations utilizing transition metal salt complexes of cupric acetate, nickel (II) acetate, cobalt (II) acetate or mixtures thereof.

REFERENCES:
patent: 4001208 (1977-01-01), Umezawa et al.
patent: 4044123 (1977-08-01), Daniels et al.
patent: 4085208 (1978-04-01), Mallams et al.
patent: 4132846 (1979-01-01), Tomioka et al.

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