Aminoethylthiophene derivatives

Details Aminoethylthiophene derivatives Aminoethylthiophene derivatives

1992-07-24

1993-05-04

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 74, 549 75, 549 77, 514821, A61K 3138, C07D33320

Patent

active

052082520

ABSTRACT:
This invention relates to aminoethylthiophene derivatives and more particularly 2-and 3-aminoethylthiophene derivatives which are useful as antiarrhythmic agents, their methods of use as antiarrhythmic agents, and novel intermediate compounds useful for preparation of the aminoethylthiophene derivatives of the invention.

REFERENCES:
patent: 4128561 (1978-12-01), Braye
patent: 4460580 (1984-07-01), Ostermayer et al.
patent: 5117000 (1992-05-01), Suzuki et al.
R. T. Gilsdorf et al., Journal of Organic Chemistry, 15 pp. 807-811 (1950).
S. Conde et al., Journal of Medicinal Chemistry, 21 (9), pp. 978-981 (1978).
J. Arrowsmith et al., in "Annual Reports in Medicinal Chemistry" J. Bristol ed., vol. 25, pp. 79-88, Academic Press, Inc., New York (1990).
M. Steinberg et al., in "Annual Reports in Medicinal Chemistry," vol. 21, pp. 95-108, Academic Press, Inc., New York (1986).

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