Aminoethyl oximes having anti-depressive activity

Details Aminoethyl oximes having anti-depressive activity Aminoethyl oximes having anti-depressive activity

1976-03-19

1978-04-25

Torrence, Dolph H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260465E, 26050117, 260566AE, 424316, 424327, A61K 3115, A61K 31275, C07C12178, C07C13100

Patent

active

040863611

ABSTRACT:
The compounds of the formula ##STR1## where Hal is Br or Cl and R is ethoxy, methoxymethyl, ethoxymethyl, cyano, methoxyethoxy or cyanomethyl when Hal is Cl and is cyano, methoxy or methoxyethoxy when Hal is Br and their salts have a strong anti-depressive activity resulting in a powerful potentiation of noradrenalin and in a strong serotonin potentiation. Monoamino oxidase inhibition does not provide a basis for the antidepressive activity of these compounds. The compounds are free from noxious side effects to a considerable extent, for example, broncho-constriction and stomach ulceration.

REFERENCES:
patent: 3692835 (1972-09-01), Van Dijk et al.

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