Aminodiol derivatives

Details Aminodiol derivatives Aminodiol derivatives

1991-06-28

1993-08-10

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546283, 548202, 548205, 5483007, 5483131, 5483151, 5483111, 549 60, 549331, 549341, 549451, C07D40106, C07D27722, C07D40906, C07D31772

Patent

active

052350576

ABSTRACT:
The invention relates to compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are hydrogen or aralkyl, R.sup.3 is alkyl, cycloalkyl or cycloalkylalkyl, R.sup.4 and R.sup.5 are identical or different and are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a heterocyclic radical and R.sup.6 and R.sup.7 are identical or different and are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl or arlkyl or R.sup.6 and R.sup.7, together with the carbon atom carrying them, are cycloalkyl. The novel compounds are prepared by a carbonyl olefination according to Wittig. They are intermediates for the preparation of pharmaceuticals, in particular of inhibitors of renin and HIV protease.

REFERENCES:
Chemical Abstracts, vol. 109, No. 13, 110855j (Sep. 26, 1988).
Chemical Abstracts, Vol. 111, No. 23, 214356e (Dec. 4, 1989).
Chemical Abstracts, vol. 113, No. 3, 24297e (Jul. 16, 1990).
Chemical Abstracts, vol. 113, 231702y (Dec. 17, 1990).

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