Aminocyclohexylesters and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142315, 5142312, 5142288, 514360, 514361, 514374, 514378, 540543, 540602, 540612, 544 70, 544153, 544158, 544171, 544172, 544143, 544146, 548124, 548125, 548131, 548143, 548215, 548240, C07D22314, C07D41300, A61K 3155, A61K 31535

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active

058859845

ABSTRACT:
Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.

REFERENCES:
patent: 2954380 (1960-09-01), Shapiro
patent: 4438130 (1984-03-01), Kaplan
patent: 4656182 (1987-04-01), Horwell
patent: 4737493 (1988-04-01), Horwell
patent: 4855316 (1989-08-01), Horwell et al.
Abraham et al., "Antiarrhythmic Properties of Tetrodotoxin Against Occlusion-Induced Arrhythmias in the Rat: A Novel Approach to the Study of the Antiarrhythmic Effects of Ventricular Sodium Channel Blockade," J. Pharmacol. Exp. Ther. 251(3):1166-1173, 1989.
Curtis and Walker, "Quantification of arrhythmias using scoring systems: an examination of seven scores in an in vivo model of regional myocardial ischaemia," Cardiovasc. Res. 22:656-665, 1988.
Hall, Jr. et al., "Aminomercuration of Olefins," Journal of Organic Chemistry 37(20):3069-3075, 1972.
Penz et al., "A New ECG Measure (RSh) for Detecting Possible Sodium Channel Blockade in Vivo in Rats," J. Pharmacol. Methods 27(1):51-58, 1992.
Pugsley et al., "Antiarrhythmic effects of U-50,488H in rats subject to coronary artery occlusion," Eur. J. Pharmacol. 212:15-19, 1992.
Pugsley et al., "Cardiovascular actions of the .kappa.-agonist, U-50,488H, in the absence and presence of opioid receptor blockade," Br. J. Pharmacol. 105:521-526, 1992.
Pugsley et al., "Electrophysiological and antiarrhythmic actions of the .kappa. agonist PD 129290, and its R,R (+)-enantiomer, PD 129289," Br. J. Pharmacol. 110:1579-1585, 1993.
Pugsley et al., "Cardiovascular Actions of U50,488H and Related Kappa Agonists," Cardiovascular Drug Reviews 11(2):151-164, 1993.
Shapiro et al., "Aminocyclohexyl Esters," Journal of the American Chemical Society 81:3993-3996, 1959.
Laboratori Farmaceutici A. Malizia S.p.A., "Esters of 4-piperidinocyclohexanol," Chemical Abstracts 63: 1773b, 1965.
Laboratori Farmaceutici A. Malizia S.p.A., "Piperidine-n-cyclohexanol esters," Derwent Abstract No. 66-16021F, 1966.

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