Aminocyclohexylesters and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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548527, 544153, 544158, 544 70, 544172, 544373, 544376, 514253, 514278, 514323, 514324, 514320, 514518, 546196, 546219, 546221, 5142395, 514429, 514255, 5142335, 514315, 514317, 514409, 514422, 5142352, 544171, 544399, 544146, 544143, 546239, 546 15, 546201, 546202, 548400, 548578, 548407, 548525, 540612, 540602, 540543, C07D21122, C07D295096, A61K 31445, A61K 31535

Patent

active

056375832

ABSTRACT:
Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.

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Laboratori Farmaceutici A. Malizia, Derwent, Abstract No. 66-16021F (1965).
Laboratori Farmaceutici A. Malizia, Chemical Abstract 63:1773b (1965).
Abraham et al., "Antiarrhythmic Properties of Tetrodotoxin Against Occlusion-Induced Arrhythmias in the Rat: A Novel Approach to the Study of the Antiarrhythmic Effects of Ventricular Sodium Channel Blockade," J. Pharmacol. Exp. Ther. 251:1166-1173, 1989. Month of Publication Not Provided.
Curtis and Walker, "Quantification of arrhythmias using scoring systems: an examination of seven scores in an in vivo model of regional myocardial ischaemia," Cardiovasc. Res. 22:656-665, 1988. Month of Publication Not Provided.
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Pugsley et al., "Antiarrhythmic effects of U-50,488H in rats subject to coronary artery occlusion," Eur. J. Pharmacol. 212:15-19, 1992. Month of Publication Not Provided.
Pugsley et al., "Cardiovascular actions of the .kappa.-agonist, U-50,488H, in the absence and presence of opioid receptor blockade," Br. J. Pharmacol. 105:521-526, 1992. Month of Publication Not Provided.
Pugsley et al., "Electrophysiological and antiarrhythmic actions of the .kappa. agonist PD 129290, and its R,R(+)-enantiomer, PD 129289," Br. J. Pharmacol. 110:1579-1585, 1993. Month of Publication Not Provided.
Pugsley et al., "Cardiovascular Actions of U50,488H and Related Kappa Agonists," Cardiovascular Drugs Reviews 11:151-164, 1993. Month of Publication Not Provided.

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