Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S153000, C548S218000, C548S303100, C548S360500, C548S453000, C548S471000, C514S367000, C514S375000, C514S387000, C514S393000, C514S405000, C514S406000, C514S412000, C514S866000

Reexamination Certificate

active

07906649

ABSTRACT:
The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

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Weber, “Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes”, Journal of Medicinal Chemistry, vol. 47, No. 17, pp. 4135-4141 (Aug. 2004).
Gao, YD. et al., “Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors”, Bioorganic & Medicinal Chemistry Letters, 2007. pp. 3877-3879, vol. 17.

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