Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1977-09-06
1983-08-02
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 136, 536 168, 435 80, A61K 3171, C07H 1522
Patent
active
043966098
ABSTRACT:
Aminocyclitol analogs of gentamicin C.sub.1, C.sub.2 and C.sub.1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an .omega.-amino-.alpha.-hydroxy-lower-alkanoyl group are prepared by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an added aminocyclitol with a mutant of Micromonospora purpurea and acylating the product with an ester of an .omega.-(N-benzyloxycarbonyl)amino-.alpha.-hydroxy-lower-alkanoic acid followed by catalytic hydrogenolysis of the benzyloxycarbonyl group.
REFERENCES:
patent: 3669838 (1972-06-01), Shier et al.
patent: 3780018 (1973-12-01), Konishi et al.
patent: 3796699 (1974-03-01), Naito et al.
patent: 3828021 (1974-08-01), Beattie et al.
patent: 4053591 (1977-10-01), Daniels et al.
Cooper et al., "J. Chem. Soc.", 1971, pp. 2876-2879.
Clarke Robert L.
Daum Sol J.
Brown Johnnie R.
Sterling Drug Inc.
Webb William G.
Wyatt B. Woodrow
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