Aminocyclitol antibiotics

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260563C, 260563P, 195 96, 536 17, C07C 8738

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active

039729303

ABSTRACT:
Aminocyclitol analogs of gentamicin C.sub.1, C.sub.2 and C.sub.1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an .omega.-amino-.alpha.-hydroxy-lower-alkanoyl group are prepared by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an added aminocyclitol with a mutant of Micromonospora purpurea and acylating the product with an ester of an .omega.-(N-benzyloxycarbonyl)amino-.alpha.-hydroxy-lower-alkanoic acid followed by catalytic hydrogenolysis of the benzyloxycarbonyl group.

REFERENCES:
patent: 3112345 (1963-11-01), Stanbury
Peck et al., J. Am. Chem. Soc. 68, (1946), pp. 776-781.
Shier et al., J. Antibiotics, vol. 26, (1973), pp. 551-561.

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