Aminocyclitol antibiotics

Details Aminocyclitol antibiotics Aminocyclitol antibiotics

1976-01-21

1977-06-07

Tanenholtz, Alvin E.

Textiles: fiber preparation

536 17, C12D 914

Patent

active

040281884

ABSTRACT:
Aminocyclitol analogs of gentamicin C.sub.1, C.sub.2 and C.sub.1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an .omega.-amino-.alpha.-hydroxy-lower-alkanoyl group are prepared by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an added aminocyclitol with a mutant of Micromonospora purpurea and acylating the product with an ester of an .omega.-(N-benzyloxycarbonyl)amino-.alpha.-hydroxy-lower-alkanoic acid followed by catalytic hydrogenolysis of the benzyloxycarbonyl group.

REFERENCES:
patent: 3669838 (1972-06-01), Shier et al.
patent: 3951746 (1976-04-01), Weinstein et al.

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