Aminocarboxylic acid derivatives

Details Aminocarboxylic acid derivatives Aminocarboxylic acid derivatives

1983-03-29

1985-07-09

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

562439, 562432, 562503, 562505, 562506, 562507, 562400, 562556, 562560, 562443, 562564, 562561, 562441, 562565, 562448, 562445, 562426, 548342, 548561, 514415, 514562, 514563, 514564, 514565, C07C10124

Patent

active

045283974

ABSTRACT:
An aminocarboxylic acid derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2, independently from each other, represent a hydrogen atom or an alkyl group which may have a substituent, and Y represents --NH-- or --S--, provided that when Y represents --NH--, at least one of R.sub.1 and R.sub.2 represents an alkyl group which may have a substituent. These compounds have excellent inhibitory activity on dipeptidase in animals, and are useful for administration in combination with carbapenem antibiotics.

REFERENCES:
patent: 2452653 (1948-11-01), Harris et al.
patent: 3950542 (1976-04-01), Kalopissis et al.
patent: 4140797 (1979-02-01), Ondetti et al.
Chemical Abstracts, vol. 60, No. 13, Jun. 1964, Abstract No. 15984c.
Chemical Abstracts, vol. 89, No. 22, Nov. 1978, Abstract No. 18659r.
Aleksier, Chem. Abst, vol. 88, #120743h (1978).

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