Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of q

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514313, 514339, 514415, 546152, 546169, 546171, 546273, 548469, A61K 3147, A61K 3144, C07D21558, C07D40100

Patent

active

055146902

ABSTRACT:
Novel compounds having potassium channel activating activity and useful, for example, as antiischemic agents are disclosed. These compounds have the general formula ##STR1## wherein A is ##STR2## or a single bond to complete an indoline nucleus; X is --O--, --S-- or --NCN; and the R groups are as defined herein.

REFERENCES:
patent: 3872119 (1975-03-01), Kathawala
patent: 3953506 (1976-04-01), Spicer et al.
patent: 4428881 (1984-01-01), Hedrich et al.
patent: 5140031 (1992-08-01), Atwal et al.
Chemical Abstract vol, 113, No. 171,904d, Sekiya et al, 1990, "Benzene-condensed cyclic amine .beta.-amino carboxamides as antitachycardiacs and vasodilators".
A. P. Terent'ev et al., "Optically active isocyanates. III. Synthesis and spectropolarimetric study of optically active N-derivative of urea", Chemical Abatracts, vol. 71, 1969, Abstract No. 69992h, p. 250.
Jose Bermudez et al., "5-Hydroxytryptamine (5-HT.sub.3) Receptor Antagonists. 2. 1-Indolinecarboxamides", J.Med. Chem., 1990, vol. 33, pp. 1929-1932.
Paul D. Leeson et al., "4-Amido-2-carboxytetrahydroquinolines, Structure-Activity Relationships for Antagonism at the Glycine Site of the NMDA Receptor", J. Med. Chem, 1992, vol. 35, pp. 1954-1968.
John L. Hughes et al., "Cardiovascular Activity of Aromatic Guanidine Compounds", J. Med. Chem., 1975, vol. 18, No. 11, pp. 1077-1088.
M. Mazza et al., "N-Acilindoline Ad Attivita Fitotossica", Farmaco. Ed. Sci., vol. 31, No. 10, 1976, pp. 746-754.
H. J. Petersen et al., J. of Med. Chem., vol. 21, No. 8, 1978:773-781, Washington, D.C. (1978).
V. A. Ashwood et al., "Synthesis and Antihypertensive Activity of 4-(Cyclic Amido)-2H-1-benzopyrans", J. Med. Chem., 1986:29:2194-2201. (1986).
C. R. Rasmussen et al., "Improved Procedures of Cycloalkyl-, Arylalkyl-, and Arylthioureas", Synthesis, Juen 1988:456-459. (1988).
V. V. Mozolis et al., "Preparation of N-Substituted Thiourea", Russian Chemical Reviews, 42(7):1973:587-595. (1973).
J. M. Evans et al., "Synthesis and Antihypertensive Activity of Su,bstituted trans-4-Amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols" , J. Med. Chem., 1983:26:1582-1589. (1983).
R. W. Lang et al., "Synthesis of Selectivity Trifluoromethylated Pyridine Derivatives as Potential Antihypertensives", Helvetica Chimica Acta, 1988:71:596-601. (1988).
P. Sebok et al., "Selective Synthesis of Analogues of the Natural Prococenes Synthesis and Regioselective (-Alkylation of 6-Chloro-and 6-Tert-Butyl-7,8-Dihydroxy-2,2-Dimethyl-4-Chromanones", Heterocycles, 1988:27:2595-2607.
P. Teixidor et al., "Improved Preparation of Precocene II, Unexpected Results in the Reduction of Alkoxy Substituted Acetophenones and 4-Chromanones with Sodium Borohydride", Heterocycles, 1988:27:2459-2465.
A. Banerji et al., "Enolats of o-Hydroxyacetophenones: Novel Synthesis of 2,2-Dialkyl-4-Chromanones", Tetrahedron Let., 1979:38:3685-3686.
G. Ariamala et al., "A Simple Route for the Synthesis of 4-Chlorochromenes and Chroman-4-ones", Tetrahedron Let., 1988:vol. 29, No. 28:3487-3488.
R. Albrecht et al., CA77:88182j, (1972), Abstract of Chim. Ther., 1972:7(1):90-13.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of q does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of q, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of q will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1227500

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.