Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-08-02
2005-08-02
Shameem, Golam M M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S496000, C564S155000, C562S465000, C558S415000
Reexamination Certificate
active
06924307
ABSTRACT:
Aminobutylic acid derivatives of the formula (I):wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are useful for prevention and/or treatment of diseases, for example, rheumatoid diseases, arthrosteitis, osteoarthritis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, cornea ulcer, metastasis, invasion or growth of tumor cells, autoimmune disease, disease caused by vascular emigration or infiltration of leukocytes, arterialization, multiple sclerosis, arota aneurysm, endometriosis, restenosis after PTCA, unstable angina, acute myocardial infarction, transient ischemic attack.
REFERENCES:
patent: 2702820 (1955-02-01), Tummes et al.
patent: 6294573 (2001-09-01), Curtin et al.
patent: 6420427 (2002-07-01), Takahashi et al.
patent: 1024134 (2000-08-01), None
Renil, Manet et al, “PEGA supports for combinatorial peptide synthesis and solid-phase enzymic library assays,” J. Pept. Sci., 1998, vol. 4, No. 3, pp. 195-210.
Luo, Jin et al, “Efficient Syntheses of Pyrofolic Acid and Pteroyl Azide, Reagents for the Production of Carboxyl-Differentiated Derivatives of Folic Acid”, J. Am. Chem. Sco., 1997, vol. 119, No. 42, pp. 10004-10013.
Chapman, K.T. et al; “Inhibition of matrix metalloproteinases by P1 substituted N-carboxylalkyl dpeptides”; Bioorganic & Medicinal Chemistry Lettes. vol. 6, No. 3, Feb. 6, 1996).
Sugiura Tsuneyuki
Takahashi Kanji
Ono Pharmaceutical Co. Ltd.
Shameem Golam M M
Stevens Davis Miller & Mosher L.L.P.
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