Aminobutyramide conjugate and a pharmaceutical composition...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S002600, C514S012200, C514S019300, C514S023000

Reexamination Certificate

active

07074775

ABSTRACT:
A compound is provided that has the formulain-line-formulae description="In-line Formulae" end="lead"?NH2CH2CH2CH2C(O)N—R  (I)in-line-formulae description="In-line Formulae" end="tail"?where R is a moiety capable of crossing the blood brain barrier and is as a free compound serotonin, dopamine blood brain barrier (BBB) peptide, membrane translocating protein, TAT peptides, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptidetransferrin, glucosylamnine, amino saccharin, lactylamine, leucine, tryptophan, glutamate and amino cholines.

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“Adjuvant” Stedmans Medical Dictionary, 27thEdition. (2004). accessed Aug. 11, 2005 at http://216.251.232.159/semdweb/internetsomd/ASP/1486797.asp 1 page.
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N.N. Suvorov, et al. Bioorganicheskaya Khimiya (1976) 2(6), pp. 729-736.

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