Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-03-15
1994-07-05
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514323, 514339, 514417, 544144, 544373, 546200, 546272, 548477, A61K 31395, A61K 3140, C07D20948
Patent
active
053267605
ABSTRACT:
Aminobutanoic acids of the following formula (I): ##STR1## where R.sup.1 -R.sup.5 are a variety of substituents, novel intermediates, a pharmaceutical composition for treating inflammatory diseases, demyelinating diseases, and tumor metastasis, methods for such treatment and processes for preparing compounds of formula (I).
REFERENCES:
patent: 4511504 (1985-04-01), McCullagh et al.
L. A. Liotta et al., "Metastatic potential correlates with enzymatic degradation of basement membrane collagen:," Nature, 284, 67-68 (1980).
Chantry, et al., "metalloendoprotease Cleavage of 18.2- and 14.1-Kilodalton Basic Proteins Dissociating from Rodent Myelin Membranes Generates 10.0- and 5.9-Kilodalton C-Terminal Fragments", J. Neurochem. 50, No. 3, 688-694 (1988).
Gravallese, et al., "In Situ Hybridization Studies of Stromelysim and Collagen Messenger RNA Expression in Rheumatoid Synovium", Arthritis and Rheumatism, 34, No. 9, 1076-1084 (1991).
Wooley, et al., "Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint", Arthritis and Rheumatism, 20 No. 6, 1231-1239 (1977).
Brown Peter J.
Drewry David H.
McElroy Andrew B.
Salovich James M.
Schoenen Frank J.
Glaxo Inc.
Richter Johann
Smith Gardiner F. H.
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