Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-08-18
1996-01-30
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564307, A61K 31135
Patent
active
054880688
ABSTRACT:
Antiatherosclerotic compounds are provided which have the structure ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, lower alkyl, or arylalkyl, at least one of R.sup.1 and R.sup.2 being other than hydrogen, and R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen, lower alkyl, lower alkenyl, halo, alkoxy, aryl or arylalkyl. A method for treating atherosclerosis employing the above compounds is also provided.
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Bjorkhem, I., et al, "The Antioxidant Butylated Hydroxytoluene Protects Against Atherosclerosis", Arteriosclerosis and Thrombosis, vol. 11, No. 1, Jan./Feb. 1991, pp. 15-22.
Kita, T., et al, "Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia", Proc. Natl. Acad. Scir. USA, vol. 84, pp. 5928-5931, Aug. 1987, Medical Sciences.
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Biller Scott A.
Parker Rex A.
Bristol--Myers Squibb Company
Raymond Richard L.
Rodney Burton
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