Aminobenzophenones as inhibitors of IL-1β and TNF-α

Details Aminobenzophenones as inhibitors of IL-1β and TNF-α Aminobenzophenones as inhibitors of IL-1β and TNF-α

2005-05-24

2005-05-24

Killos, Paul J. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S024000, C560S027000

Reexamination Certificate

active

06897236

ABSTRACT:
The present invention relates to compounds of formula (I) wherein R1, R2and R3independently represent one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, or phenyl; R1and R2further represented by nitro and R3by carboxy; R4represents hydrogen, (C1-C3)alkyl, or allyl; Q represents a bond, or —C(R6)(R7)(—O—C═O)—, in which formula R6and R7independently represent hydrogen, trifluoromethyl, or (C1-C4)alkyl; Y represents either (C5-C15)alkyl, (C2-C15)olefinic group, (C3-C10)monocyclic hydrocarbon, or phenyl, any of which may be optionally substituted with one or more, same or different substituents represented by the formula R5; or (C1-C4)alkyl substituted with at least one or more substituents with the formula R5; or Y represents a group of formula —CH2—(Z—O)n—Z where Z is a (C1-C3)alkyl, where n is a integer>1 and no continuous linear sequence of atoms in the group Y>15; R5represents halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, azido, nitro, —COOH, —CONH2, —CONHR′, or —COONR′R′ wherein R′ stands for (C1-C3)alkyl; X represents oxygen or sulphur, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compounds are valuable in the human and veterinary therapy.

REFERENCES:
patent: 9832730 (1998-07-01), None

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