Aminobenzoic acid derivatives

Details Aminobenzoic acid derivatives Aminobenzoic acid derivatives

1997-02-24

1998-03-03

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142305, 514299, 544 90, 546 79, 546101, 546112, A61K 31435, C07D26512, C07D22122

Patent

active

057234728

ABSTRACT:
To provide a compound which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio. An aminobenzoic acid derivative represented by the general formula (I) or (II) or a pharmacologically acceptable salt thereof: ##STR1## ##STR2## {wherein A represents a group represented by formula --CH.sub.2 --X--CH.sub.2 -- (wherein X represents O, >N--R.sup.6 or >CHR.sup.7 (wherein R.sup.6 represents lower alkyl and R.sup.7 represents hydrogen or lower alkoxy)), etc.; D and E each represents a group represented by formula --(CH.sub.2).sub.3 --, etc., and R.sup.2 represents lower alkyl, etc.}; R.sup.9 represents alkynyl; R.sup.10 represents amino, etc.; R.sup.11 represents halogen; R.sup.12 and R.sup.13 each represent lower alkyl; a is an integer of 1 to 5; and b is an integer of 0 to 5!.

REFERENCES:
patent: 4472413 (1984-09-01), Hadley et al.
patent: 5256671 (1993-10-01), Ladduwahetty et al.
patent: 5389643 (1995-02-01), Miyazawa et al.
Chemical Abstracts, 120: 106775 (1993).

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