Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-07-18
1996-04-30
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514183, 514216, 5142275, 5142305, 514255, 514301, 514302, 514305, 540468, 540472, 540477, 540582, 544 59, 544105, 544162, 544349, 546112, 546114, 546115, A61K 31445, C07D29504, C07D22122, C07D21158
Patent
active
055125794
ABSTRACT:
To provide a compound which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio. An aminobenzoic acid derivative represented by the general formula (I) or (II) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1 represents a group represented by the formula: ##STR2## {wherein A represents a group represented by formula --CH.sub.2 --X--CH.sub.2 -- (wherein X represents O, >N--R.sup.6 or >CHR.sup.7 (wherein R.sup.6 represents lower alkyl and R.sup.7 represents hydrogen or lower alkoxy)), etc.; D and E each represents a group represented by formula --(CH.sub.2).sub.3 --, etc., and R.sup.2 represents lower alkyl. etc.}; R.sup.9 represents alkynyl; R.sup.10 represents amino, etc.; R.sup.11 represents halogen; R.sup.12 and R.sup.13 each represent lower alkyl; a is an integer of 1 to 5; and b is an integer of 0 to 5!.
REFERENCES:
patent: 4472413 (1984-09-01), Hadley et al.
patent: 5256671 (1993-10-01), Ladduwahetty et al.
patent: 5389643 (1995-02-01), Miyazawa et al.
Chemical Abstract, 120:106775, 1993.
Abe Shinya
Hirota Kazuo
Hoshino Yorohisa
Kameyama Takaaki
Miyazawa Shuhei
Eisai Co. Ltd.
Gupta Yogendra N.
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