Aminobenzimidazoles as selective melanin concentrating...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S254060, C514S322000, C544S121000, C544S370000, C546S199000

Reexamination Certificate

active

07030113

ABSTRACT:
The present invention discloses compounds of formula Iwherein Ar, Z, m, n, p, R1and R8are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

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patent: WO-2004100875 (2004-11-01), None
Masako Shimada et al, Mice Lacking Melanin-Concentraling Hormone are Hypophagic and Lean,Nature1998, 396: 670-674.
Beth Borowsky et al., Antidepressant, Anxiolytic and Anorectic Effects of a Melanin-Concentrating Hormone-1 Receptor Antagonists,Nature Medicine2002, 8:825-828.
PCT International Search Report dated Sep. 30, 2004 for corresponding PCT Application No. PCT/US2004/032494 - 4 Pages.

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